主な原著論文

Shiraishi R, Cancila G, Kumegawa K, Torrejon J, Basili I, Bernardi F, Silva PBGD, Wang W, Chapman O, Yang L, Jami M, Nishitani K, Arai Y, Xiao Z, Yu H, Lo Re V, Marsaud V, Talbot J, Lombard B, Loew D, Jingu M, Okonechnikov K, Sone M, Motohashi N, Aoki Y, Pfister SM, Chavez L, Hoshino M, Maruyama R, Ayrault O, Kawauchi D. Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression. Dev Cell. 59(17):2302-2319. (2024) Selected as a featured article.

Zheng T, Ghasemi DR, Okonechnikov K, Korshunov A, Sill M, Maass KK, Benites Goncalves da Silva P, Ryzhova M, Gojo J, Stichel D, Arabzade A, Kupp R, Benzel J, Taya S, Adachi T, Shiraishi R, Gerber NU, Sturm D, Ecker J, Sievers P, Selt F, Chapman R, Haberler C, Figarella-Branger D, Reifenberger G, Fleischhack G, Rutkowski S, Donson AM, Ramaswamy V, Capper D, Ellison DW, Herold-Mende CC, Schuller U, Brandner S, Driever PH, Kros JM, Snuderl M, Milde T, Grundy RG, Hoshino M, Mack SC, Gilbertson RJ, Jones DTW, Kool M, Deimling AV, Pfister SM, Sahm F^*, Kawauchi D^*, Pajtler KW^*. Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion-positive supratentorial ependymomas. Cancer Discov. 11(9):2230-2247. (2021) ^*Co-corresponding author

Haag D, Mack N, Benites Goncalves da Silva P, Statz B, Clark J, Tanabe K, Sharma T, Jager N, Jones DTW, Kawauchi D, Wernig M^*, Pfister SM^*. H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model. Cancer Cell. 39(3):407-422. (2021)

Kutscher LM, Okonechnikov K, Batora NV, Clark J, Silva PBG, Vouri M, van Rijn S, Sieber L, Statz B, Gearhart MD, Shiraishi R, Mack N, Orr BA, Korshunov A, Gudenas BL, Smith KS, Mercier AL, Ayrault O, Hoshino M, Kool M, von Hoff K, Graf N, Fleischhack G, Bardwell VJ, Pfister SM, Northcott PA, Kawauchi D^*. Functional loss of a noncanonicalk BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation. Genes Dev. 34(17-18):1161-1176. (2020)

Pajtler KW, Wei Y, Okonechnikov K, Silva PBG, Vouri M, Zhang L, Brabetz S, Sieber L, Gulley M, Mauermann M, Wedig T, Mack N, Imamura Kawasawa Y, Sharma T, Zuckermann M, Andreiuolo F, Holland E, Maass K, Korkel-Qu H, Liu HK, Sahm F, Capper D, Bunt J, Richards LJ, Jones DTW, Korshunov A, Chavez L, Lichter P, Hoshino M, Pfister SM, Kool M, Li W^*, Kawauchi D^*. YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis. Nat Commun. 10(1):3914. (2019)

Forget A^*, Martignetti L, Puget S, Calzone L, Brabetz S, Picard D, Montagud A, Liva S, Sta A, Dingli F, Arras G, Rivera J, Loew D, Besnard A, Lacombe J, Pages M, Varlet P, Dufour C, Yu H, Mercier AL, Indersie E, Chivet A, Leboucher S, Sieber L, Beccaria K, Gombert M, Meyer FD, Qin N, Bartl J, Chavez L, Okonechnikov K, Sharma T, Thatikonda V, Bourdeaut F, Pouponnot C, Ramaswamy V, Korshunov A, Borkhardt A, Reifenberger G, Poullet P, Taylor MD, Kool M, Pfister SM, Kawauchi D^*, Barillot E^*, Remke M^*, Ayrault O^*. Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. Cancer Cell.34(3):379-395. (2018) *Co-corresponding author.

Kawauchi D^*, Ogg RJ, Liu L, Shih DJH, Finkelstein D, Murphy BL, Rehg JE, Korshunov A, Calabrese C, Zindy F, Phoenix T, Kawaguchi Y, Gronych J, Gilbertson RJ, Lichter P, Gajjar A, Kool M, Northcott PA, Pfister SM, Roussel MF^*. Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells. Oncogene. 36(37):5231-5242. (2017) *Co-corresponding author.

Feng W^#, Kawauchi D^#,*, Korkel-Qu H, Deng H, Serger E, Sieber L, Lieberman JA, Jimeno-Gonzalez S, Lambo S, Hanna BS, Harim Y, Jansen M, Neuerburg A, Friesen O, Zuckermann M, Rajendran V, Gronych J, Ayrault O, Korshunov A, Jones DT, Kool M, Northcott PA, Lichter P, Cortes-Ledesma F,  Pfister SM*, Liu HK*. Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme. Nat Commun. 8:14758. (2017) ^#Co-first author. *Co-corresponding author.

Lin CY, Erkek S, Tong Y, Yin L, Federation AJ, Zapatka M, Haldipur P, Kawauchi D, Risch T, Warnatz HJ, Worst BC, Ju B, Orr BA, Zeid R, Polaski DR, Segura-Wang M, Waszak SM, Jones DT, Kool M, Hovestadt V, Buchhalter I, Sieber L, Johann P, Chavez L, Groschel S, Ryzhova M, Korshunov A, Chen W, Chizhikov VV, Millen KJ, Amstislavskiy V, Lehrach H, Yaspo ML, Eils R, Lichter P, Korbel JO, Pfister SM^*, Bradner JE^*, Northcott PA^*. Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature. 530(7588):57-62. (2016)

Vo BT, Wolf E, Kawauchi D, Gebhardt A, Rehg JE, Finkelstein D, Walz S, Murphy BL, Youn YH, Han YG, Eilers M, Roussel MF^*. The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity. Cancer Cell. 29(1):5-16. (2016)

Zuckermann M, Hovestadt V, Knobbe-Thomsen CB, Zapatka M, Northcott PA, Schramm K, Belic J, Jones DT, Tschida B, Moriarity B, Largaespada D, Roussel MF, Korshunov A, Reifenberger G, Pfister SM, Lichter P, Kawauchi D^*, Gronych J^*. Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling. Nat Commun.6:7391. (2015) *Co-corresponding author.

Northcott PA, Lee C, Zichner T, Stutz AM, Erkek S, Kawauchi D, Shih DJ, Hovestadt V, Zapatka M, Sturm D, Jones DT, Kool M, Remke M, Cavalli FM, Zuyderduyn S, Bader GD, VandenBerg S, Esparza LA, Ryzhova M, Wang W, Wittmann A, Stark S, Sieber L, Seker-Cin H, Linke L, Kratochwil F, Jager N, Buchhalter I, Imbusch CD, Zipprich G, Raeder B, Schmidt S, Diessl N, Wolf S, Wiemann S, Brors B, Lawerenz C, Eils J, Warnatz HJ, Risch T, Yaspo ML, Weber UD, Bartholomae CC, von Kalle C, Turanyi E, Hauser P, Sanden E, Darabi A, Siesjo P, Sterba J, Zitterbart K, Sumerauer D, van Sluis P, Versteeg R, Volckmann R, Koster J, Schuhmann MU, Ebinger M, Grimes HL, Robinson GW, Gajjar A, Mynarek M, von Hoff K, Rutkowski S, Pietsch T, Scheurlen W, Felsberg J, Reifenberger G, Kulozik AE, von Deimling A, Witt O, Eils R, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Korbel JO, Wechsler-Reya RJ^*, Pfister SM^*. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature. 511(7510):428-34. (2014)

Wolf E, Gebhardt A, Kawauchi D, Walz S, von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M^*. Miz1 is required to maintain autophagic flux. Nat Commun. 4:2535. (2013)

Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stutz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FM, Wang X, Remke M, Wu X, Chiu RY, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li Y, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AG, Thiessen NT, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DT, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fevre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EM, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognar L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PH, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJ, Korbel JO, Pfister SM, Marra MA, Taylor MD^*. Subgroup-specific structural variation across 1,000 medulloblastoma genomes Nature. 488(7409):49-56. (2012)

Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Becksfort J, Gupta P, Ma J, Easton J, Vadodaria B, Onar-Thomas A, Lin T, Li S, Pounds S, Paugh S, Zhao D, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Gajjar A, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ^*. Novel mutations target distinct subgroups of medulloblastoma. Nature.488(7409):43-8. (2012)

Kawauchi D, Robinson G, Uziel T, Gibson P, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson RJ^*, Roussel MF^*. A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell. 21(2):168-180. (2012) Selected as a featured article.

総説

Feng W^*, Kawauchi D^*, Wan F^*. Editorial: Molecular characteristics and personalized treatment for pediatric brain tumors. Front Oncol. 12:1114280. (2022) ^*Co-corresponding author.

Wang W, Shiraishi R, Kawauchi D. Shh signalling in cerebellar development and cancer. Front Cell Dev Biol. 10:864035 (2022)

Shiraishi R, Kawauchi D. Epigenetic regulation in medulloblastoma pathogenesis revealed by genetically engineered mouse models. Cancer Sci. 112(8):2948-2957. (2021)

Presenilin deficiency enhances tau phosphorylation and its secretion. Yang Sun, Sadequl Islam, Tomohisa Nakamura, Taisuke Tomita, Makoto Michikawa*, Kun Zou*.  Journal of Neurochemistry 168(9), 2956-2973, 2024

Presenilin: A Multi-Functional Molecule in the Pathogenesis of Alzheimer’s Disease and Other Neurodegenerative Diseases. Yang Sun, Sadequl Islam, Makoto Michikawa, Kun Zou*. International journal of molecular sciences 25(3), 1757, 2024

Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE. Yuan Gao, Yang Sun, Sadequl Islam, Tomohisa Nakamura, Taisuke Tomita, Kun Zou*, Makoto Michikawa*. Frontiers in Aging Neuroscience 15, 1098034, 2023

Aβ42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood-brain barrier model. Tomohisa Nakamura, Tadahiro Hashita, Yuxin Chen, Yuan Gao, Yang Sun, Sadequl Islam, Hiroyuki Sato, Yasuyuki Shibuya, Kun Zou, Tamihide Matsunaga, Makoto Michikawa. Molecular brain 16(1), 15, 2023

鄒鶤*,　道川誠. アルツハイマー病におけるプレセニリンの役割.　臨床神経科学 40:10, 1320-1322, 2022.

Apolipoprotein E4 inhibits γ-secretase activity via binding to the γ-secretase complex. Yang Sun, Sadequl Islam, Yuan Gao, Tomohisa Nakamura, Kun Zou*, Makoto Michikawa*. Journal of Neurochemistry 164(6), 858-874, 2022

Presenilin is essential for ApoE secretion, a novel role of presenilin involved in Alzheimer’s disease pathogenesis. Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Arshad Ali Noorani, Tong Li, Philip C Wong, Noriyuki Kimura, Etsuro Matsubara, Kensaku Kasuga, Takeshi Ikeuchi, Taisuke Tomita, Kun Zou*, Makoto Michikawa*. The Journal of neuroscience 42(8), 1574-1586, 2022

Presenilin Deficiency Increases Susceptibility to Oxidative Damage in Fibroblasts. Kun Zou*, Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Hiroto. Komano, Taisuke Tomita, Makoto Michikawa*. Frontiers in aging neuroscience 14, 902525-902525, 2022

Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer’s disease mouse model. Yu Fujita, Kuniyuki Kano, Shigenobu Kishino, Toshihiro Nagao, Xuefeng Shen, Chiharu Sato, Hatsune Hatakeyama, Yume Ota, Sho Niibori, Ayako Nomura, Kota Kikuchi, Wataru Yasuno, Sho Takatori, Kazunori Kikuchi, Yoshitake Sano , Taisuke Tomita, Toshiharu Suzuki, Junken Aoki, Kun Zou, Shunji Natori, Hiroto Komano. Scientific Reports 11(1), 9749, 2021

Cholesterol Regulates Exosome Release in Cultured Astrocytes. Mohammad Abdullah, Tomohisa Nakamura, Taslima Ferdous, Yuan Gao, Yuxin. Chen, Kun Zou, Makoto Michikawa. Frontiers in immunology 12, 722581-722581, 2021

Oral dysfunctions and cognitive impairment/dementia. Tomohisa Nakamura, Kun Zou, Yasuyuki Shibuya, Makoto Michikawa. Journal of neuroscience research 99(2), 518-528, 2020

High temperature promotes amyloid β-protein production and γ-secretase complex. formation via Hsp90. Arshad Ali Noorani, Hitoshi Yamashita, Yuan Gao, Sadequl Islam, Yang Sun, Tomohisa Nakamura, Hiroyuki Enomoto, Kun Zou*, Makoto Michikawa*. The Journal of Biological Chemistry 295(52), 18010-18022, 2020

Engulfment of Toxic Amyloid β-protein in Neurons and Astrocytes Mediated by MEGF10. Yu Fujita, Tomoji Maeda, Chiharu Sato, Masaya Sato, Hatsune Hatakeyama, Yume. Ota, Nozomi Iwabuchi, Komaki Tatesawa, Ayako Nomura, Kun Zou, Hiroto Komano. Neuroscience 443, 1-7, 2020

Current Biomarkers for Alzheimer’s Disease: From CSF to Blood. Kun Zou*, Mohammad Abdullah, Makoto Michikawa Journal of Personalized Medicine 10(3), 2020

Interaction between Angiotensin Receptor and β-Adrenergic Receptor Regulates the Production of Amyloid β-Protein. Kota Kikuchi, Yu Fujita, Xuefeng Shen, Junjun Liu, Tomoki Terakawa, Daiki. Nishikata, Sho Niibori, Takayuki Ito, Kazuyuki Ashidate, Takuya Kikuchi, Yu Kikuchi, Tomoji Maeda, Kun Zou*, Hiroto Komano*. Biological & Pharmaceutical Bulletin 43(4), 731-735, 2020

A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous. ACE deletion exacerbate Alzheimer’s disease pathology in mice. Shuyu Liu, Fujiko Ando, Yu Fujita, Junjun Liu, Tomoji Maeda, Xuefeng Shen, Kota Kikuchi, Aoi Matsumoto, Mirai Yokomori , Chiaki Tanabe-Fujimura, Hiroshi Shimokata, Makoto Michikawa, Hiroto Komano, Kun Zou*. The Journal of Biological Chemistry 294(25), 9760-9770, 2019

Iron treatment inhibits Aβ42 deposition in vivo and reduces Aβ42/Aβ40 ratio. Xuefeng Shen, Junjun Liu, Yu Fujita, Shuyu Liu, Tomoji Maeda, Kota Kikuchi, Toshiki Obara, Arisa Takebe, Rieko Sayama, Tomoko Takahashi, Ai Matsue, Koichiro Sera, Makoto Michikawa, Hiroto Komano, Kun Zou*. Biochemical and Biophysical Research Communications 512(4), 653-658, 2019

Flotillin is a Novel Diagnostic Blood Marker of Alzheimer’s Disease. Mohammad Abdullah, Noriyuki Kimura, Hiroyasu Akatsu, Yoshio Hashizume, Taslima Ferdous, Takuto Tachita, Shinsuke Iida, Kun Zou, Etsuro Matsubara, Makoto Michikawa. Journal of Alzheimer’s Disease 72(4), 1165-1176, 2019