The research proposal focused on Grp4 medulloblastoma, a tumor for which knowledge of progression mechanisms is limited. We aim to analyze the interactions between tumor cells and neurons by utilizing a newly developed N1-SRC-induced cancer model and patient-derived xenograft (PDX) models. Given that Grp4 medulloblastoma exhibits a neural gene signature, strong interaction between cancer and neuronal cells is suspected.

The research will focus on genomic and transcriptomic analysis of extrachromosomal DNA in pediatric tumors.

Dr. Owen Shojiro Chapman from the Lukas Chavez Lab at UCSD has joined our medulloblastoma research. He will be responsible for and strengthening the field of cancer bioinformatics.

The Institute of Neuroscience hosted the “Brain Fest.” We were greatly inspired by the many young students from diverse universities and research backgrounds who participated. Although we were unable to offer lab tours this time due to our ongoing relocation, we aim to prepare thoroughly for the next event to give everyone a deeper insight into our brain tumor research. For more details, please click here.

The 74th Brain Medical and Biological Research Meeting was held jointly with the 3rd Young KYOUEN of the Japanese Society for Neurochemistry, chaired by Prof. Kazunobu Sawamoto, Director of the Institute of Neuroscience. Professor Kawauchi delivered an invited lecture on ‘Understanding the Mechanisms of Pediatric Brain Tumor Formation Based on (Epi)genomic Abnormalities and Exploring Novel Therapies. For more details, please refer to the following link.